In 2004, he began writing a blog entitled Respectful Insolence at Blogspot under the pen name Orac. He has criticized the prevalence of pseudoscience in the medical field including the use of alternative therapies, acupuncture, detoxification, and the use of dietary treatment to manage autism. Gorski is a vocal skeptic of alternative medicine, known to confront pseudoscience. Skepticism of alternative medicine Skeptics Steven Novella, Harriet Hall, David Gorski, and Rachael Dunlop on a panel at The Amaz!ng Meeting 2012 In 2008, Gorski and Yun Chen published an article titled "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5" that investigated the use of microRNA to regulate angiogenesis. Semenza (citing Mauceri and others), "are more hypoxic than normal cells," allowing for "tumor cells to be killed without major systemic side effects." Gorski's work with Helena Mauceri and others, published in Nature in 1998 as "Combined effects of angiostatin and ionizing radiation in antitumour therapy" studied the "combined effects of angiostatin" (a protein occurring in several animal species) "and ionizing radiation in anti-tumor therapy" led to investigation into the selective destruction of tumor cells, which according to a 1999 study by Gregg L. This research has been used in anti-tumor therapeutic research, including an observation that angiogenesis inhibitors enhanced the therapeutic effects of ionizing radiation "by preventing repair of radiation damage to endothelial cells," and in determining the potential of combinational therapies to allow reduction of the dosages in toxic conventional treatments while sustaining tumor regression when combined with specific antibodies and radiation therapy. Gorski's 1999 article "Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation", characterizing the effects of angiogenesis inhibitors on the effectiveness of anti-tumor therapies, has been cited over 900 times according to PubMed. Gorski is listed as a founder of the Institute for Science in Medicine and as a member of the American Society of Clinical Oncology. He became the co-director of the Michigan Breast Oncology Quality Initiative in 2013. In 2009, he was appointed the cancer liaison physician for the American College of Surgeons Committee on Cancer. He is a professor of surgery and oncology at the Wayne State University School of Medicine, whose laboratory conducts research on transcriptional regulation of vascular endothelial cell phenotype, as well as the role of metabotropic glutamate receptors in breast cancer. In 2008, Gorski joined the Wayne State University School of Medicine and became affiliated with the Karmanos Cancer Institute. He was awarded research grants by The Breast Cancer Research Foundation in 2008, 2009, and 2010. In 2007 he received the Advanced Clinical Research Award in Breast Cancer from the American Society of Clinical Oncology. In the mid 2000s, Gorski taught surgery as an associate professor at the Rutgers Cancer Institute of New Jersey and the Robert Wood Johnson Medical School, at Rutgers University. Prior to 2005, he was active on the early internet message boards of Usenet participating in flame wars. His dissertation was entitled "Homeobox Gene Expression and Regulation in Vascular Myocytes." Gorski continued his residency (1993–96) and completed a surgical oncology research fellowship (1996–99) at The University of Chicago. Gorski completed a PhD in cellular physiology at Case Western Reserve University in 1994. He entered a residency in general surgery in 1989 at the University Hospitals of Cleveland. ![]() He went on to study medicine at the University of Michigan, earning an MD in 1988. Gorski attended a Roman Catholic high school. ![]() A prolific blogger, he writes as Orac at Respectful Insolence, and as himself at Science-Based Medicine where he is the managing editor. Gorski is an outspoken skeptic and critic of alternative medicine and the anti-vaccination movement. He specializes in breast cancer surgery at the Karmanos Cancer Institute. Wayne State University School of Medicineĭavid Henry Gorski is an American surgical oncologist and professor of surgery at Wayne State University School of Medicine.Township Council Lawrence Township operates under the Council/ Manager form of government and has done so since 1970. Under this form, the major duties of government are allocated as follows: Lawrence Township Elected Officials ( to view an individual's bio click on their picture or name)Ĭlick here to access the Township Council Agendas and Minutes.
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